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Search by protein name, UniProt number, IPI number, or 15 AA P-site sequence.
Updated: 2017 Aug. 1
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Warning
– Occasionally the phosphosites shown below in more divergent species may be slightly mis-aligned with our algorithm and the calculated Conservation Score may be higher than shown.
Phosphosite
Conservation Score
Human Protein:
PTPN6
All Species:
28.48
Human Site:
Y505
Identified Species:
56.97
UniProt:
P29350
Number Species:
11
Phosphosite Substitution
Charge Score:
0.09
Phosphosite
Sequences
Species
Species
Scientific Name
UniProt ID
NCBI Ref Seq ID
AA#
Mr(Da)
P-Site
-7
-6
-5
-4
-3
-2
-1
0
1
2
3
4
5
6
7
Human
Homo sapiens
P29350
NP_002822.2
595
67561
Y505
M
V
Q
T
E
A
Q
Y
K
F
I
Y
V
A
I
Chimpanzee
Pan troglodytes
XP_001163468
596
67703
Y506
M
V
Q
T
E
A
Q
Y
K
F
I
Y
V
A
I
Rhesus Macaque
Macaca mulatta
XP_001110915
597
67615
Y507
M
V
Q
T
E
A
Q
Y
K
F
I
Y
V
A
I
Dog
Lupus familis
XP_543844
595
67669
Y505
M
V
Q
T
E
A
Q
Y
K
F
I
Y
V
A
I
Cat
Felis silvestris
Mouse
Mus musculus
P29351
595
67540
Y505
M
V
Q
T
E
A
Q
Y
K
F
I
Y
V
A
I
Rat
Rattus norvegicus
P81718
613
69560
Y507
M
V
Q
T
E
A
Q
Y
K
F
I
Y
V
A
I
Wallaby
Macropus eugenll
Platypus
Ornith. anatinus
XP_001519010
556
61792
E467
C
A
E
H
D
A
P
E
Y
K
L
R
S
L
Q
Chicken
Gallus gallus
Q90687
593
67964
G503
M
V
R
S
Q
R
S
G
M
V
Q
T
E
A
Q
Frog
Xenopus laevis
NP_001085766
594
68095
G503
M
V
R
Q
Q
R
S
G
M
V
Q
T
E
A
Q
Zebra Danio
Brachydanio rerio
NP_956254
589
66986
S499
M
M
V
R
D
Q
R
S
G
M
V
Q
T
E
A
Tiger Blowfish
Takifugu rubipres
Fruit Fly
Dros. melanogaster
P29349
845
92957
Y635
L
V
Q
T
E
A
Q
Y
K
F
V
Y
Y
A
V
Honey Bee
Apis mellifera
Nematode Worm
Caenorhab. elegans
Sea Urchin
Strong. purpuratus
XP_784121
533
60826
V444
Y
K
F
V
Y
R
A
V
Q
H
Y
I
E
T
L
Poplar Tree
Populus trichocarpa
Maize
Zea mays
Rice
Oryza sativa
Thale Cress
Arabidopsis thaliana
Baker's Yeast
Sacchar. cerevisiae
Red Bread Mold
Neurospora crassa
Conservation
Percent
Protein Identity:
100
97.9
97.8
96.1
N.A.
94.4
91
N.A.
68
54.2
58.3
64.7
N.A.
33.8
N.A.
N.A.
43.3
Protein Similarity:
100
98.8
98.4
97.9
N.A.
98.1
94.9
N.A.
72.9
70.7
72
78.4
N.A.
46.9
N.A.
N.A.
60.8
P-Site Identity:
100
100
100
100
N.A.
100
100
N.A.
6.6
20
20
6.6
N.A.
73.3
N.A.
N.A.
0
P-Site Similarity:
100
100
100
100
N.A.
100
100
N.A.
26.6
40
33.3
33.3
N.A.
93.3
N.A.
N.A.
13.3
Percent
Protein Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Protein Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Identity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
P-Site Similarity:
N.A.
N.A.
N.A.
N.A.
N.A.
N.A.
Phosphosite
Consensus
Position
-7
-6
-5
-4
-3
-4
-5
0
+1
+2
+3
+4
+5
+6
+7
% Ala:
0
9
0
0
0
67
9
0
0
0
0
0
0
75
9
% A
% Cys:
9
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% C
% Asp:
0
0
0
0
17
0
0
0
0
0
0
0
0
0
0
% D
% Glu:
0
0
9
0
59
0
0
9
0
0
0
0
25
9
0
% E
% Phe:
0
0
9
0
0
0
0
0
0
59
0
0
0
0
0
% F
% Gly:
0
0
0
0
0
0
0
17
9
0
0
0
0
0
0
% G
% His:
0
0
0
9
0
0
0
0
0
9
0
0
0
0
0
% H
% Ile:
0
0
0
0
0
0
0
0
0
0
50
9
0
0
50
% I
% Lys:
0
9
0
0
0
0
0
0
59
9
0
0
0
0
0
% K
% Leu:
9
0
0
0
0
0
0
0
0
0
9
0
0
9
9
% L
% Met:
75
9
0
0
0
0
0
0
17
9
0
0
0
0
0
% M
% Asn:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% N
% Pro:
0
0
0
0
0
0
9
0
0
0
0
0
0
0
0
% P
% Gln:
0
0
59
9
17
9
59
0
9
0
17
9
0
0
25
% Q
% Arg:
0
0
17
9
0
25
9
0
0
0
0
9
0
0
0
% R
% Ser:
0
0
0
9
0
0
17
9
0
0
0
0
9
0
0
% S
% Thr:
0
0
0
59
0
0
0
0
0
0
0
17
9
9
0
% T
% Val:
0
75
9
9
0
0
0
9
0
17
17
0
50
0
9
% V
% Trp:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% W
% Tyr:
9
0
0
0
9
0
0
59
9
0
9
59
9
0
0
% Y
% Spaces:
0
0
0
0
0
0
0
0
0
0
0
0
0
0
0
% _